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PK Parameters of Jivi® in Patients ≥12 Years of Age1

PK parameters of Jivi® in the PROTECT VIII trial (arithmetic mean ± SD)1

  • Measured following a single dose (25 IU/kg and 60 IU/kg)1
  • Combined data from Phase 1 and Phase 2/3 studies.
  • Recovery value could not be calculated for one subject.
  • PK: pharmacokinetic; SD: standard deviation; AUC: area under the curve; Cmax: maximum drug concentration in plasma after single dose; t1/2: terminal half-life; MRTIV: mean residence time after an IV administration; VSS: apparent volume distribution at steady-state; CL: clearance.